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Industrial applications of LCST lower critical solution temperature UCST upper critical solution temperature critical solution temperature PHENOMENON

 With progress in emerging water-based biochemical and medical sciences, the number of studies aiming to make use of the temperature-responsive behavior of PNiPAAm (N-isopropylacrylamide) grew exponentially. Apart from PNiPAAm a LCST-type phase transition in water at around 32 °C with little change over a wide concentration range many other polymers with LCST behavior in water have been discovered, and to date numerous applications in the fields of tissue engineering, liquid chromatography, drug delivery, and bioseparation have been developed. LCST polymers were exclusively chosen for these applications

To binary system if impurities of ionic and covalent substances are added, a ternary system is

formed. For a ternary system, there are three components co-existing in a system. The addition of a third substance to a partially miscible system to increase its miscibility is known as blending. This is also called as the ‘salting-out’ in pharmaceuticals and is used to select  the best solvent for the drugs. In this process, a salt is  added to separate the aqueous phase from the organic phase. If the added salt dissolves in one of the phases only, it results in an increase in the UCST, and a decrease in the LCST, thus decreasing the miscibility of the system 3.


Reference:

pubs.acs.org

International journal of pharmaceutical science and review and research





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